Endothelial Cell Surface Heparan Sulfate (ESHS) and Synthetic Heparin Derivatives as Hemocompatible Coating for Biomaterials

2001 ◽  
Vol 32 (2) ◽  
pp. 110-115 ◽  
Author(s):  
M. Hoffmann ◽  
B. Huppertz ◽  
R. Horres ◽  
H. Baumann ◽  
R. Keller
Keyword(s):  
Endothelial Cell ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Endothelial Cell Surface ◽  
Heparin Derivatives

scholarly journals High-resolution probing heparan sulfate–antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies

2015 ◽  
Vol 17 (20) ◽  
pp. 13301-13306 ◽  
Author(s):  
Cunlan Guo ◽  
Xian Fan ◽  
Hong Qiu ◽  
Wenyuan Xiao ◽  
Lianchun Wang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Single Molecule ◽  
Binding Sites ◽  
Specific Interactions ◽  
Endothelial Cell Surface ◽  
Afm Probe

Using an antithrombin functionalized AFM probe, the specific interactions between antithrombin and heparan sulfate on endothelial cell surface were determined, revealing previously unexpected diverse binding sites as well as critical roles of N-, 2-O- and 6-O-sulfation in the interactions.

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